Ttp diagnosis and treatment Thrombotic thrombocytopenic purpura (TTP) is a rare blood disorder in which thrombi (blood clots) form in small blood vessels throughout your body. These blood clots can restrict the flow of oxygen-rich blood to your organs, causing a number of life-limiting complications. Treatments include plasma therapy, medication and surgery. 1 ttp-hus 2 How is TTP treated? Therapeutic plasma exchange (plasmapheresis) is used to treat acquired TTP. In this procedure, the liquid part of your Plasma infusion is used to treat inherited TTP. For this treatment, donor plasma is given through an intravenous (IV). 3 ttp sykdom 4 Thrombotic thrombocytopenic purpura (TTP) is an acute, fulminant disorder characterized by thrombocytopenia and microangiopathic hemolytic anemia. Other manifestations may include alterations in level of consciousness and sometime kidney failure. 5 INTRODUCTION Thrombotic thrombocytopenic purpura (TTP) is a thrombotic microangiopathy (TMA) caused by severely reduced activity of the von Willebrand factor-cleaving protease ADAMTS It is characterized by small-vessel platelet-rich thrombi that cause thrombocytopenia, microangiopathic hemolytic anemia, and sometimes organ damage. 6 The panel agreed on 11 recommendations based on evidence ranging from very low to moderate certainty. For first acute episode and relapses of iTTP, the panel made a strong recommendation for adding corticosteroids to therapeutic plasma exchange (TPE) and a conditional recommendation for adding rituximab and caplacizumab. 7 itp 8 Trombotisk trombocytopenisk purpura (TTP) er en sykdom som gir lavt innhold av blodplater i blodet, lav blodprosent som følge av ødeleggelse. 9 Guidelines on the diagnosis and management of thrombotic thrombocytopenic purpura George JN, Cuker A. Acquired TTP: Initial treatment. 10 Thrombotic thrombocytopenic purpura is suspected in patients with suggestive symptoms, thrombocytopenia, and anemia. If the disorder is suspected, urinalysis and renal function tests, CBC, peripheral blood smear, reticulocyte count, serum LDH, haptoglobin, ADAMTS13 activity and autoantibody (inhibitor) assays, serum bilirubin (direct and. 11